P.S.S Mankon was founded on the 23rd of October 1978. As everything goes through stages of development so did Presbyteian Secondary School Mankon. In 1961, the school had been opened as Women's Teachers Training College Mankon (WTTC Mankon) with 38 women, the principal being Na Webah.

The school was later hired by the government for about a year and in 1978, P.S.S mankon was opened for both boys and girls. P.S.S came in to existence as C.P.C Bali annex. In 1997 P.S.S Mankon became a high school with 88 students in the second cycle and has been growing. Presbyterian Secondary School was opened by the Presbyterian Church in Cameroon, on the 23rd of October 1978, with the first principal being Mr. Memoh Zachariah from 1978-1987. Then Mr. Francis Ndzuenyuiy became principal till 1994. Rev.S.A.K Ndingwan took over from 1994 till present. Today P.S.S Mankon is known for high academic performance, discipline, and sports. P.S.S Mankon today has a population of 780 students with about 57 staff members.

The school so far has sent out nineteen batches of graduates who together are recognized as PEMEXANS. Below is an extract from a speech Mr. Memoh Zachariah gave in June of 2002, to PEMEXANS in Washington D.C about those early days of PSS Mankon.

Special thanks to the administrators of the school. Our thanks to Pa MEMOH who started the school on a good administrative stand. Being the first principal, he built a solid foundation for the school. The school was known for its high academics, always amongst the best schools in the G.C.E Ordinary Level performance. Discipline could be found amongst the students of P.S.S. Pa we greatly appreciate your efforts in the school. In remembrance of our first principal, two girl's dormitories and two boy's dorms were named after him "MEMOH HOUSE"